Cryolipolysis FAQ Science

Cryolipolysis Research / Fat Freeze

We understand newspapers and blogs are not the most reliable form of research. Therefore, we have drawn information from journals detailing scientific studies that tested the effectiveness of Cryolipolysis, to get rid of any of your doubts about the procedure. If you wish to read more around this, we have listed the journal and authors names to assist you in your research. We want you to be 100% sure before deciding on a treatment, and we believe these journals will help.

Cryolipolysis Research Results Before and after picture


Journal: Safety, Tolerance, and patient Satisfaction with Non-invasive Cryolipolysis  (Christine C. Dierickx, Jean- Michel Mazer, Mila Sand, Sylvie Koenig, And Valerie Arigon)

Cryolipolysis Research Results: “The investigators treated 518 patients. No significant side effects or adverse events were reported. The procedure was well tolerated, with 89% of respondents reporting a positive perception of treatment duration and 96% reporting minimal to tolerable discomfort. Survey results demonstrated 73% patient satisfaction and that 82% of patients would recommend the Cryolipolysis procedure to a friend. Caliper measurements demonstrated 23% reduction in fat layer thickness at three months. Abdomen, back, and flank treatment sites were most effective, with 86% of subjects showing improvement per investigator assessment” Original Cryolipolysis Research Journal Original Cryolipolysis Research Journal


Journal: Cryolipolysis (fat freeze) for subcutaneous Fat layer Reduction (Mathew M. Avram, MD, JD1 and Rosemary S. Harry, MSBME2)

Cryolipolysis Research Results: “Cryolipolysis has demonstrated efficacy in both human and animal studies. Histology findings also confirm the selective reduction of fat in both humans and animals, with evidence of a gradual thinning of the fat layer over a period of two to four months. Importantly, cryolipolysis has not produced any significant adverse side effects in studies to date and any noted effects have been minor and temporary” Original Cryolipolysis Research Journal

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Journal: Synergistic Effects of Cryolipolysis and Shock Waves for Non-Invasive Body Contouring

(G. A. Ferraro, F. De Francesco, C. Cataldo, F. Rossano, G. Nicoletti, F. D’Andrea)

Cryolipolysis Research Results: “ The procedure significantly reduced the circumference in the treated areas, significantly diminishing fat thickness. The mean reduction in fat thickness after treatment was 3.02 cm. Circumference was reduced by a mean of 4.45cm. Weight was unchanged during the treatment, and no adverse effects were observed. Histologic and immunohistochemical analysis confirmed a gradual reduction of fat tissue by programmed cell death. Moreover, the reduction in thickness was accompanied by a significant improvement in microcirculation, and thus, the cellulite. The safety of the method also has been highlighted because it is accompanied by no significant increase in serum liver enzymes or serum lipids” Original Cryolipolysis Research Journal


Journal: Non-Invasive Selective Cryolipolysis and Reperfusion Recovery for Localized Natural Fat Reduction and Contouring (Gordon H. Sasaki, MD, FACS; Natalie Abelev, RN; and Ana Tevez-Ortiz, RN)

Cryolipolysis Research Results: “Thirty minutes into the cooling phase, sub-dermal temperatures of patients in the PSG declined precipitously from pre-treatment levels and remained low until the end of treatment. During recovery, sub-dermal temperatures of the only subject who received massage returned faster and to higher levels than the temperatures of subjects who did not receive massage. Patients in the CTG who were available for follow-up measurements at 6 months

(n = 85) demonstrated an average fat reduction of 21.5% by caliper measurements; 6 random patients from this group also showed an average of 19.6% fat reduction by ultrasound imaging at 6 months. Global assessments were highest for the abdomen, hip, and brassiere rolls. Minimal side effects were observed, and patients experienced no significant downtime.” Original Cryolipolysis Research Journal


Cryolipolysis Research Journal: Cryolipolysis for Non-Invasive Fat Cell Destruction Initial Results from a Pig Model ( Brian Zelickson, Barbara M. Egbert, Y Jessica Preciado, Z John Allison, Kevin Springer, Robert W. Rhoades, and Dieter Manstein)

Cryolipolysis Research cryolipolysis research Results: “The treatments resulted in a significant reduction in the superficial fat layer without damage to the overlying skin. An inflammatory response triggered by cold-induced apoptosis of adipocytes preceded the reduction in the fat layer. Evaluation of lipids over a 3-month period following treatment demonstrated that cholesterol and triglyceride values remained normal.” Original Cryolipolysis Research Journal